Negative results intelligence for drug discovery — query measured failures via MCP.
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First seen 2 Oct 2026. One server, whatever directories list it: each directory listing keeps its own page and history.
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35
Tools
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Tools
| Tool | Description | Behaviour |
|---|---|---|
| get_compound | A compound (structure, name, max clinical phase) + its full negative profile across modalities/sources. | Read-only |
| get_coverage | Per-modality and per-source coverage stats (honest Phase-1 numbers). | Read-only |
| get_finding_provenance | Full provenance + detail for a single finding by id. | Read-only |
| get_model_card | Per-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533). | Read-only |
| get_target_landscape | Target 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533). | Read-only |
| list_models | Summary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC. | Read-only |
| list_top_targets | Coverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other). | Read-only |
| search_adc_linker_failures | ADC failures attributed to linker chemistry. | Read-only |
| search_admet_failures | Small-molecule ADMET failures. | Read-only |
| search_admet_failures_all_modalities | ADMET failures across ALL modalities. | Read-only |
| search_ancestry_specific_failures | Ancestry-specific CRISPR failures. | Read-only |
| search_bispecific_format_failures | Bispecific format/engineering failures. | Read-only |
| search_developability_failures | Antibody developability failures. | Read-only |
| search_drug_drug_interaction_failures | Drug-drug interaction failures. | Read-only |
| search_failed_adcs | ADCs that failed at any stage. | Read-only |
| search_failed_bispecifics | Bispecifics that failed at any stage. | Read-only |
| search_failed_clinical_antibodies | Discontinued/terminated clinical antibodies. | Read-only |
| search_failed_essentiality_screens | Non-dependency / failed essentiality screens. | Read-only |
| search_failed_guides | Failed/ineffective CRISPR guides. | Read-only |
| search_failed_oligonucleotides | ASOs/siRNAs that failed engagement/developability. | Read-only |
| search_failed_peptide_therapeutics | Failed peptide therapeutics. | Read-only |
| search_failed_protacs | PROTACs that failed degradation/ternary/permeability. | Read-only |
| search_failed_replications | Findings that failed to replicate. | Read-only |
| search_failed_selectivity | Small molecules that failed selectivity. | Read-only |
| search_failed_vaccines | Failed/terminated vaccines (by pathogen/indication). | Read-only |
| search_inactive_compounds | Inactive small-molecule compound-target pairs. | Read-only |
| search_indication_history | ALL failed approaches for an indication across every modality. | Read-only |
| search_mechanism_failures | Approaches that failed for a mechanism (by target). | Read-only |
| search_oligo_delivery_failures | Oligonucleotide delivery failures. | Read-only |
| search_pathogen_history | Vaccine + antimicrobial + antibody failures for a pathogen. | Read-only |
| search_peptide_stability_issues | Peptide stability/half-life failures. | Read-only |
| search_protac_e3_issues | PROTAC E3-ligase recruitment / ternary failures. | Read-only |
| search_safety_failures | Clinical/preclinical safety failures across modalities. | Read-only |
| search_target_history | ALL failed approaches against a target across every modality. | Read-only |
| search_vaccine_immunogenicity_failures | Failed vaccine immunogen designs. | Read-only |
| Directory | Listing | Tier | First seen |
|---|---|---|---|
| Official MCP Registry | ai.nullary/nullary | - | 2 Oct 2026 |